Recurrent Microdeletions at Xq27.3-Xq28 and Male Infertility: A Study in the Czech Population.

ABSTRACT:

Background

Genetic causes of male infertility are hypothesized to involve multiple types of mutations, from single gene defects to complex chromosome rearrangements. Recently, several recurrent X-chromosome microdeletions (located in subtelomeric region of the long arm) were reported to be associated with male infertility in Spanish and Italian males. The aim of our study was to test their prevalence and infertility association in population of men from the Czech Republic.

Methods

107 males with pathological sperm evaluation resulting in nonobstructive infertility were compared to 131 males with normal fecundity. X-chromosome microdeletions were assessed by +/- PCR with three primer pairs for each region Xcnv64 (Xq27.3), Xcnv67 (Xq28) and Xcnv69 (Xq28). The latter microdelet

SUBMITTER: Chylikova B 

PROVIDER: S-EPMC4892532 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature