Genetics of Unilateral and Bilateral Age-Related Macular Degeneration Severity Stages.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is a common disease causing visual impairment and blindness. Various gene variants are strongly associated with late stage AMD, but little is known about the genetics of early forms of the disease. This study evaluated associations of genetic factors and different AMD stages depending on unilateral and bilateral disease severity.

Methods

In this case-control study, participants were assigned to nine AMD severity stages based on the characteristics of each eye. 18 single nucleotide polymorphisms (SNPs) were genotyped and attempted to correlate with AMD severity stages by uni- and multivariate logistic regression analyses and trend analyses. Area under the receiver operating characteristic curves (AUC) were calculated.

Resul

SUBMITTER: Schick T 

PROVIDER: S-EPMC4892556 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature