Common Marker Genes Identified from Various Sample Types for Systemic Lupus Erythematosus.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) is a complex auto-immune disease. Gene expression studies have been conducted to identify SLE-related genes in various types of samples. It is unknown whether there are common marker genes significant for SLE but independent of sample types, which may have potentials for follow-up translational research. The aim of this study is to identify common marker genes across various sample types for SLE.

Methods

Based on four public microarray gene expression datasets for SLE covering three representative types of blood-born samples (monocyte; peripheral blood mononuclear cell, PBMC; whole blood), we utilized three statistics (fold-change, FC; t-test p value; false discovery rate adjusted p value) to scrutinize genes simultaneously regula

SUBMITTER: Bing PF 

PROVIDER: S-EPMC4892593 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature