Procaine Inhibits Osteo/Odontogenesis through Wnt/β-Catenin Inactivation.

ABSTRACT:

Introduction

Periodontitis is a complex pathology characterized by the loss of alveolar bone. The causes and the mechanisms that promote this bone resorption still remain unknown. The knowledge of the critical regulators involved in the alteration of alveolar bone homeostasis is of great importance for developing molecular therapies. Procaine is an anesthetic drug with demethylant properties, mainly used by dentists in oral surgeries. The inhibitor role of Wnt signaling of procaine was described in vitro in colon cancer cells.

Methods

In this work we evaluated the role of procaine (1 uM) in osteo/odontogenesis of rat bone marrow mesenchymal stem cells. Similarly, the mechanisms whereby procaine achieves these effects were also studied.

Results

Procaine administration

SUBMITTER: Herencia C 

PROVIDER: S-EPMC4892678 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature