Nicotine intake from electronic cigarettes on initial use and after 4 weeks of regular use.

ABSTRACT:

Introduction

Electronic cigarettes (EC) have the potential to generate a substantial public health benefit if there is a switch from smoking to EC use on a population scale. The nicotine delivery from EC is likely to play a major role in their attractiveness to smokers. We assessed nicotine delivery from a first-generation EC and the effect of experience with its use on nicotine intake.

Methods

Six smokers provided pharmacokinetic (PK) data after their first use of EC and again following 4 weeks of use.

Results

The peak nicotine levels were achieved within 5 min of starting the EC use, which suggests that EC may provide nicotine via pulmonary absorption. There were large individual differences in nicotine intake. Compared with the PK profile when using EC for the firs

SUBMITTER: Hajek P 

PROVIDER: S-EPMC4892703 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature