Structural-functional coupling changes in temporal lobe epilepsy.

ABSTRACT: Alterations in both structural connectivity (SC) and functional connectivity (FC) have been reported in temporal lobe epilepsy (TLE). However, the relationship between FC and SC remains less understood. This study used functional connectivity MRI and diffusion tensor imaging to examine coupling of FC and SC within the limbic network of TLE, as well as its relation to epilepsy duration, regional changes, and disease laterality in 14 patients with left TLE, 10 with right TLE, and 11 healthy controls. Structural and functional networks were separately constructed and the correlation estimated between structural and functional connectivity. This measure of SC-FC coupling was compared between left/right TLE and controls, and correlated with epilepsy duration. Elastic net regression was used to

SUBMITTER: Chiang S 

PROVIDER: S-EPMC4892844 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature