Ontology highlight
ABSTRACT:
SUBMITTER: Tapia N
PROVIDER: S-EPMC4892893 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Nature communications 20120101
The evolutionary origins of the gene network underlying cellular pluripotency, a central theme in developmental biology, have yet to be elucidated. In mammals, Oct4 is a factor crucial in the reprogramming of differentiated cells into induced pluripotent stem cells. The Oct4 and Pou2 genes evolved from a POU class V gene ancestor, but it is unknown whether pluripotency induced by Oct4 gene activity is a feature specific to mammals or was already present in ancestral vertebrates. Here we report t ...[more]