Patterns of Cortical Synchronization in Isolated Dystonia Compared With Parkinson Disease.

ABSTRACT:

Importance

Isolated dystonia and Parkinson disease (PD) are disorders of the basal gangliothalamocortical network. They have largely distinct clinical profiles, but both disorders respond to deep brain stimulation (DBS) in the same subcortical targets using similar stimulation paradigms, suggesting pathophysiologic overlap. We hypothesized that, similar to PD, isolated dystonia is associated with elevated cortical neuronal synchronization.

Objective

To investigate the electrophysiologic characteristics of the sensorimotor cortex arm-related area using a temporary subdural electrode strip in patients with isolated dystonia and PD undergoing DBS implantation in the awake state.

Design, setting, and participants

An observational study recruited patients scheduled for DBS

SUBMITTER: Miocinovic S 

PROVIDER: S-EPMC4892933 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature