Liver transplantation for hepatocellular carcinoma beyond the Milan criteria.

ABSTRACT:

Objective

Liver transplantation is an optimal radical therapy for selected patients with hepatocellular carcinoma. The stringent organ allocation system driven by the Milan criteria has been challenged by alternative sets of expanded criteria. Careful analysis is needed to prove that the Milan criteria can be expanded safely and effectively.

Design

This study collectively reviewed 6012 patients of hepatocellular carcinoma from the China Liver Transplant Registry. Expanded criteria were evaluated to characterise an optimised expansion with acceptable outcomes beyond the Milan criteria.

Results

Compared with the Milan criteria, Valencia, University of California, San Francisco, University Clinic of Navarra and Hangzhou criteria provided an expansion of 12.4%, 16.3%, 19.

SUBMITTER: Xu X 

PROVIDER: S-EPMC4893115 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature