Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery.

ABSTRACT:

Objectives

Preventing postoperative recurrence after ileocolonic resection (ICR) for Crohn's disease (CD) is challenging. Defining the disturbances of the microbial composition and community structure after ICR and their link with early disease recurrence is crucial.

Design

Microbiota composition (fingerprinting and 16S rDNA sequencing) and community structure (correlation networks of bacterial species) were assessed from ileal mucosa sampled in 20 patients undergoing ICR and 6 months later during endoscopy from above (neoterminal ileum) and below (subanastomotic colon) the surgical anastomosis.

Results

ICR had a dramatic effect on gut microbial ecosystem. At surgery, CD mucosa harboured a dysbiotic microbiota with high proportions of α/β Proteobacteria and Bacilli. S

SUBMITTER: Mondot S 

PROVIDER: S-EPMC4893116 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature