Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial.

ABSTRACT:

Background

Rebamipide is a gastroprotective agent with promising results against gastric damage induced by non-steroidal anti-inflammatory drugs. The present study evaluated if rebamipide protects against naproxen-induced gastric damage in healthy volunteers. Changes in gastric PGE2 tissue concentration were also evaluated.

Methods

After a preliminary endoscopy to rule out previous gastric macroscopic damage, twenty-four healthy volunteers of both sexes were divided into 2 groups. One group received sodium naproxen 550 mg b.i.d. plus placebo for 7 days, while the other group received sodium naproxen 550 mg b.i.d. plus rebamipide 100 mg b.i.d. At the end of treatment, a new endoscopy was performed. Gastric macroscopic damage was evaluated by the Cryer score and by the modifie

SUBMITTER: Gagliano-Juca T 

PROVIDER: S-EPMC4893238 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature