Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients.

ABSTRACT:

Background

Sarcoidosis is a granulomatous systemic inflammatory disease in which more than 90 % of all patients develop pulmonary manifestations. Several gene associations have previously been described, but established and clinically useful biomarkers are still absent. This study aimed to find proteins in bronchoalveolar lavage (BAL) fluid that can be associated with the disease.

Methods

We developed and performed profiling of 94 selected proteins in BAL fluid and serum samples obtained from newly diagnosed and non-treated patients with sarcoidosis. Using multiplexed immunoassays, a total of 317 BAL and 217 serum samples were analyzed, including asthmatic patients and healthy individuals as controls.

Results

Our analyses revealed increased levels of eight proteins in

SUBMITTER: Hamsten C 

PROVIDER: S-EPMC4893268 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature