The Orthology Ontology: development and applications.

ABSTRACT:

Background

Computational comparative analysis of multiple genomes provides valuable opportunities to biomedical research. In particular, orthology analysis can play a central role in comparative genomics; it guides establishing evolutionary relations among genes of organisms and allows functional inference of gene products. However, the wide variations in current orthology databases necessitate the research toward the shareability of the content that is generated by different tools and stored in different structures. Exchanging the content with other research communities requires making the meaning of the content explicit.

Description

The need for a common ontology has led to the creation of the Orthology Ontology (ORTH) following the best practices in ontology construction.

SUBMITTER: Fernandez-Breis JT 

PROVIDER: S-EPMC4893294 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature