Structural and molecular features of intestinal strictures in rats with Crohn's-like disease.

ABSTRACT:

Aim

To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease (CD).

Methods

Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studi

SUBMITTER: Talapka P 

PROVIDER: S-EPMC4893462 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature