Identification of responders to inhaled corticosteroids in a chronic obstructive pulmonary disease population using cluster analysis.

ABSTRACT:

Objectives

To identify clusters of patients who may benefit from treatment with an inhaled corticosteroid (ICS)/long-acting β2 agonist (LABA) versus LABA alone, in terms of exacerbation reduction, and to validate previously identified clusters of patients with chronic obstructive pulmonary disease (COPD) (based on diuretic use and reversibility).

Design

Post hoc supervised cluster analysis using a modified recursive partitioning algorithm of two 1-year randomised, controlled trials of fluticasone furoate (FF)/vilanterol (VI) versus VI alone, with the primary end points of the annual rate of moderate-to-severe exacerbations.

Setting

Global.

Participants

3255 patients with COPD (intent-to-treat populations) with a history of exacerbations in the past year.

Int

SUBMITTER: Hinds DR 

PROVIDER: S-EPMC4893846 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature