Objective and specific tracking of anhedonia via event-related potentials in individuals with cocaine use disorders.

ABSTRACT:

Background

Hyposensitivity to non-drug reward, behaviorally manifested as anhedonia, is a hallmark of chronic substance use. Anhedonia is a transdiagnostic symptom underpinned by neurobiochemical disturbances in the reward circuit, yet an objective measure to assess anhedonia severity still eludes the field. We hypothesized that the Reward Positivity (RewP) component of the event-related potentials (ERPs) will specifically track anhedonia as the RewP is attributed to the same brain regions that are also implicated in anhedonia.

Methods

Forty-six individuals with cocaine use disorders (iCUD) performed a gambling task predicting whether they would win or lose money on each trial, while ERP data was acquired. RewP in response to predicted win trials was extracted from the ERPs

SUBMITTER: Parvaz MA 

PROVIDER: S-EPMC4893885 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature