Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors.

ABSTRACT: Glioblastoma multiforme (GBM) is a fatal brain tumor characterized by infiltration beyond the margins of the main tumor mass and local recurrence after surgery. The blood-brain barrier (BBB) poses the most significant hurdle to brain tumor treatment. Convection-enhanced delivery (CED) allows for local administration of agents, overcoming the restrictions of the BBB. Recently, polymer nanoparticles have been demonstrated to penetrate readily through the healthy brain when delivered by CED, and size has been shown to be a critical factor for nanoparticle penetration. Because these brain-penetrating nanoparticles (BPNPs) have high potential for treatment of intracranial tumors since they offer the potential for cell targeting and controlled drug release after administration, here we investiga

SUBMITTER: Saucier-Sawyer JK 

PROVIDER: S-EPMC4893898 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature