Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster).

ABSTRACT: In the socially monogamous prairie voles (Microtus ochrogaster), the development of a social bonding is indicated by the formation of partner preference, which involves a variety of environmental and neurochemical factors and brain structures. In a most recent study in female prairie voles, we found that treatment with the histone deacetylase inhibitor trichostatin A (TSA) facilitates the formation of partner preference through up-regulation of oxytocin receptor (OTR) and vasopressin V1a receptor (V1aR) genes expression in the nucleus accumbens (NAcc). In the present study, we tested the hypothesis that TSA treatment also facilitates partner preference formation and alters OTR and V1aR genes expression in the NAcc in male prairie voles. We thus observed that central injection of TSA dose-d

SUBMITTER: Duclot F 

PROVIDER: S-EPMC4893910 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature