Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen.

ABSTRACT: Ionizing radiation causes depletion of hematopoietic cells and enhances the risk of developing secondary hematopoietic malignancies. Vitamin E analog gamma-tocotrienol (GT3), which has anticancer properties, promotes postirradiation hematopoietic cell recovery by enhancing spleen colony-forming capacity, and provides protection against radiation-induced lethality in mice. However, the underlying molecular mechanism involved in GT3-mediated postirradiation survival is not clearly understood. Recent studies have shown that natural dietary products including vitamin E provide a benefit to biological systems by modulating microRNA (miR) expression. In this study, we show that GT3 differentially modulates the miR footprint in the spleen of irradiated mice compared to controls at early times (da

SUBMITTER: Ghosh SP 

PROVIDER: S-EPMC4893953 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature