Fragile X Mental Retardation Protein expression in the retina is regulated by light.

ABSTRACT: Fragile X Mental Retardation Protein (FMRP) is a RNA-binding protein that modulates protein synthesis at the synapse and its function is regulated by glutamate. The retina is the first structure that participates in vision, and uses glutamate to transduce electromagnetic signals from light to electrochemical signals to neurons. FMRP has been previously detected in the retina, but its localization has not been studied yet. In this work, our objectives were to describe the localization of FMRP in the retina, to determine whether different exposure to dark or light stimulus alters FMRP expression in the retina, and to compare the pattern in two different species, the mouse and chick. We found that both FMRP mRNA and protein are expressed in the retina. By immunohistochemistry analysis we foun

SUBMITTER: Guimaraes-Souza EM 

PROVIDER: S-EPMC4893986 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature