Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.

ABSTRACT:

Background

To examine the relationship between reported high serum or red blood cell (RBC) folate status and adverse health outcomes.

Methods

We systematically searched PubMed/Medline and EMBASE (to May 2013), with no limits by study type, country or population, to identify studies reporting high folate concentrations in association with adverse health outcomes. Two reviewers screened studies and extracted data. Study quality was assessed.

Results

We included 51 articles, representing 46 studies and 71 847 participants. Quantiles were used by 96% of studies to identify high folate concentrations. Eighty-three percent of serum folate and 50% of RBC folate studies reported a high folate cutoff that corresponded with a clinically normal concentration. Increasing values o

SUBMITTER: Colapinto CK 

PROVIDER: S-EPMC4894484 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature