Heterogeneity of the translational machinery: Variations on a common theme.

ABSTRACT: In all organisms the universal process of protein synthesis is performed by the ribosome, a complex multi-component assembly composed of RNA and protein elements. Although ribosome heterogeneity was observed already more than 40 years ago, the ribosome is still traditionally viewed as an unchangeable entity that has to be equipped with all ribosomal components and translation factors in order to precisely accomplish all steps in protein synthesis. In the recent years this concept was challenged by several studies highlighting a broad variation in the composition of the translational machinery in response to environmental signals, which leads to its adaptation and functional specialization. Here, we summarize recent reports on the variability of the protein synthesis apparatus in diverse or

SUBMITTER: Sauert M 

PROVIDER: S-EPMC4894553 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature