Hippocampal place cell and inhibitory neuron activity in disrupted-in-schizophrenia-1 mutant mice: implications for working memory deficits.

ABSTRACT:

Background

Despite the prevalence of working memory deficits in schizophrenia, the neuronal mechanisms mediating these deficits are not fully understood. Importantly, deficits in spatial working memory are identified in numerous mouse models that exhibit schizophrenia-like endophenotypes. The hippocampus is one of the major brain regions that actively encodes spatial location, possessing pyramidal neurons, commonly referred to as 'place cells', that fire in a location-specific manner. This study tests the hypothesis that mice with a schizophrenia-like endophenotype exhibit impaired encoding of spatial location in the hippocampus.

Aims

To characterize hippocampal place cell activity in mice that exhibit a schizophrenia-like endophenotype.

Methods

We recorded CA1 place

SUBMITTER: Mesbah-Oskui L 

PROVIDER: S-EPMC4894816 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature