Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews.

ABSTRACT: Drug addiction is viewed as a maladaptive memory induced by contextual cues even in the abstinent state. However, the variations of hedonia and appetite induced by the context during the abstinence have been neglected. To distinguish the representative behaviors between hedonia and appetite, micro-behaviors in abstinent animal such as psycho-activity and drug seeking behaviors were observed in morphine conditioned place preference (CPP). To confirm the different effects of reward between drug and natural reward, a palatable food CPP paradigm was compared in current work. After a 10-day training in CPP with morphine or food, the preference was tested on day 1, 14, 28, and the changes of micro-behaviors were analyzed further. Our data showed that tree shrews treated with morphine performed m

SUBMITTER: Duan Y 

PROVIDER: S-EPMC4894903 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature