Study design and methods for a randomized crossover trial substituting brown rice for white rice on diabetes risk factors in India.

ABSTRACT: India has the second largest number of people with diabetes in the world following China. Evidence indicates that consumption of whole grains can reduce the risk of type 2 diabetes. This article describes the study design and methods of a trial in progress evaluating the effects of substituting whole grain brown rice for polished (refined) white rice on biomarkers of diabetes risk (glucose metabolism, dyslipidemia, inflammation). This is a randomized controlled clinical trial with a crossover design conducted in Chennai, India among overweight but otherwise healthy volunteers aged 25-65 y with a body mass index ≥23 kg/m(2) and habitual rice consumption ≥200 g/day. The feasibility and cultural appropriateness of this type of intervention in the local environment will also be examined. If th

SUBMITTER: Wedick NM 

PROVIDER: S-EPMC4895199 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature