Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis.

ABSTRACT:

Background

Tuberculosis (TB) is a serious infectious disease in that 90% of those latently infected with Mycobacterium tuberculosis present no symptoms, but possess a 10% lifetime chance of developing active TB. To prevent the spread of the disease, early diagnosis is crucial. However, current methods of detection require improvement in sensitivity, efficiency or specificity. In the present study, we conducted a microarray experiment, comparing the gene expression profiles in the peripheral blood mononuclear cells among individuals with active TB, latent infection, and healthy conditions in a Taiwanese population.

Results

Bioinformatics analysis revealed that most of the differentially expressed genes belonged to immune responses, inflammation pathways, and cell cycle contro

SUBMITTER: Lee SW 

PROVIDER: S-EPMC4895247 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature