Comprehensive prediction of lncRNA-RNA interactions in human transcriptome.

ABSTRACT:

Motivation

Recent studies have revealed that large numbers of non-coding RNAs are transcribed in humans, but only a few of them have been identified with their functions. Identification of the interaction target RNAs of the non-coding RNAs is an important step in predicting their functions. The current experimental methods to identify RNA-RNA interactions, however, are not fast enough to apply to a whole human transcriptome. Therefore, computational predictions of RNA-RNA interactions are desirable, but this is a challenging task due to the huge computational costs involved.

Results

Here, we report comprehensive predictions of the interaction targets of lncRNAs in a whole human transcriptome for the first time. To achieve this, we developed an integrated pipeline for predict

SUBMITTER: Terai G 

PROVIDER: S-EPMC4895283 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature