Reintegration of the regenerated and the remaining tissues during joint regeneration in the newt Cynops pyrrhogaster.

ABSTRACT: Urodele amphibians, such as newts, can regenerate a functional limb, including joints, after amputation at any level along the proximal-distal axis of the limb. The blastema can regenerate the limb morphology largely independently of the stump after proximal-distal identity has been established, but the remaining and regenerated tissues must be structurally reintegrated (matched in size and shape). Here we used newt joint regeneration as a model to investigate reintegration, because a functionally interlocking joint requires structural integration between its opposing skeletal elements. After forelimbs were amputated at the elbow joint, the joint was regenerated between the remaining and regenerated skeletal elements. The regenerated cartilage was thick around the amputated joint to make a

SUBMITTER: Tsutsumi R 

PROVIDER: S-EPMC4895332 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature