Yap/Taz transcriptional activity in endothelial cells promotes intramembranous ossification via the BMP pathway.

ABSTRACT: Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we demonstrate endothelial Yap/Taz is a novel regulator of intramembranous ossification in zebrafish. Appropriate blood flow is required for Yap/Taz transcriptional activation in endothelial cells and intramembranous ossification. Additionally, Yap/Taz transcriptional activity in endothelial cells specifically promotes intramembranous ossification. BMP expression by Yap/Taz transactivation in endothelial cells is also identified as a bridging factor between blood vessels and intrame

SUBMITTER: Uemura M 

PROVIDER: S-EPMC4895351 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature