Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity.

ABSTRACT:

Background/objectives

The uroguanylin-GUCY2C gut-brain axis has emerged as one component regulating feeding, energy homeostasis, body mass and metabolism. Here, we explore a role for this axis in mechanisms underlying diet-induced obesity (DIO).

Subjects/methods

Intestinal uroguanylin expression and secretion, and hypothalamic GUCY2C expression and anorexigenic signaling, were quantified in mice on high-calorie diets for 14 weeks. The role of endoplasmic reticulum (ER) stress in suppressing uroguanylin in DIO was explored using tunicamycin, an inducer of ER stress, and tauroursodeoxycholic acid (TUDCA), a chemical chaperone that inhibits ER stress. The impact of consumed calories on uroguanylin expression was explored by dietary manipulation. The role of uroguanylin in mecha

SUBMITTER: Kim GW 

PROVIDER: S-EPMC4895379 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature