Characterization of kidney injury molecule-1 in cats.

ABSTRACT:

Background

Kidney disease (KD) is common in older cats and presumed to arise from subclinical kidney injuries throughout life. Sensitive markers for detecting kidney injury are lacking. Kidney injury molecule 1 (KIM-1) is a useful biomarker of kidney injury in humans and rodents.

Hypothesis/objectives

Feline KIM-1 is conserved across species, expressed in kidney, and shed into urine of cats with acute kidney injury (AKI). The objectives were to characterize the feline KIM-1 gene and protein, assess available immunoassays for detecting KIM-1 in urine of cats, and identify KIM-1 expression in kidney sections.

Animals

Samples from 36 hospitalized and 7 clinically healthy cats were evaluated. Hospitalized cats were divided into 2 groups based on absence (n = 20) or presen

SUBMITTER: Bland SK 

PROVIDER: S-EPMC4895577 | biostudies-literature | 2014 Sep-Oct

REPOSITORIES: biostudies-literature