Markers of angiogenesis associated with surgical attenuation of congenital portosystemic shunts in dogs.

ABSTRACT:

Background

Dogs with congenital portosystemic shunts (CPSS) have hypoplasia of the intrahepatic portal veins. Surgical CPSS attenuation results in the development of the intrahepatic portal vasculature, the precise mechanism for which is unknown, although new vessel formation by angiogenesis is suspected.

Hypothesis

That the degree of portal vascular development and the increase in portal vascularization after CPSS attenuation is significantly associated with hepatic vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) gene expression and serum VEGF concentration.

Animals

Client-owned dogs with CPSS undergoing surgical treatment. Forty-nine dogs were included in the gene expression data and 35 in the serum VEGF data.

Materials and methods

Dogs

SUBMITTER: Tivers MS 

PROVIDER: S-EPMC4895587 | biostudies-literature | 2014 Sep-Oct

REPOSITORIES: biostudies-literature