Frequent variations in cancer-related genes may play prognostic role in treatment of patients with chronic myeloid leukemia.

ABSTRACT:

Background

Genome variability of host genome and cancer cells play critical role in diversity of response to existing therapies and overall success in treating oncological diseases. In chronic myeloid leukemia targeted therapy with tyrosine kinase inhibitors demonstrates high efficacy in most of the patients. However about 15 % of patients demonstrate primary resistance to standard therapy. Whole exome sequencing is a good tool for unbiased search of genetic variations important for prognosis of survival and therapy efficacy in many cancers. We apply this approach to CML patients with optimal response and failure of tyrosine kinase therapy.

Results

We analyzed exome variations between optimal responders and failures and found 7 variants in cancer-related genes with different

SUBMITTER: Lavrov AV 

PROVIDER: S-EPMC4895599 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature