Cognitive Function, Progression of Age-related Behavioral Changes, Biomarkers, and Survival in Dogs More Than 8 Years Old.

ABSTRACT:

Background

Canine cognitive dysfunction (CCD) is an age-dependent neurodegenerative condition dominated by changes in behavioral patterns. Cohort studies investigating cognitive status in dogs are lacking.

Objectives

To investigate cognitive function, progression of age-related behavioral changes, survival, and possible biomarkers of CCD in aged dogs.

Animals

Fifty-one dogs >8 years old; 21 with no cognitive deficits, 17 with mild cognitive impairments (MCI) and 13 with CCD.

Methods

Longitudinal study. Recruitment period of 12 months and an observational period of 24 months including a baseline and 3 planned subsequent assessments. Cognitive status was determined using validated questionnaires. Plasma Aβ-peptides were quantified using commercial ELISA assays an

SUBMITTER: Schutt T 

PROVIDER: S-EPMC4895687 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature