Inference of domain-disease associations from domain-protein, protein-disease and disease-disease relationships.

ABSTRACT:

Background

Protein domains can be viewed as portable units of biological function that defines the functional properties of proteins. Therefore, if a protein is associated with a disease, protein domains might also be associated and define disease endophenotypes. However, knowledge about such domain-disease relationships is rarely available. Thus, identification of domains associated with human diseases would greatly improve our understanding of the mechanism of human complex diseases and further improve the prevention, diagnosis and treatment of these diseases.

Methods

Based on phenotypic similarities among diseases, we first group diseases into overlapping modules. We then develop a framework to infer associations between domains and diseases through known relationships be

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4895779 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature