Ontology highlight
ABSTRACT:
SUBMITTER: Ecco G
PROVIDER: S-EPMC4896391 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Developmental cell 20160301 6
KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result in irreversible silencing. Using a target-centered functional screen, we matched murine TEs with their cognate KRAB-ZFP. We found the paralogs ZFP932 and Gm15446 to bind overlapping but distinguishable subsets of ERVK (endogenous retrovirus K), repress these elements in embryon ...[more]