HIV virological failure and drug resistance in a cohort of Tanzanian HIV-infected adults.

ABSTRACT:

Objectives

There are few data on ART failure rates and drug resistance from Tanzania, where there is a wide diversity of non-B HIV subtypes. We assessed rates and predictors of virological failure in HIV-infected Tanzanians and describe drug resistance patterns in a subgroup of these patients.

Methods

ART-naive, HIV-1-infected adults enrolled in a randomized controlled trial between November 2006 and 2008 and on ≥24 weeks of first-line NNRTI-containing ART were included. Population-based genotyping of HIV-1 protease and reverse transcriptase was performed on stored plasma from patients with virological failure (viral load >1000 copies/mL at ≥24 weeks of ART) and at baseline, where available.

Results

A total of 2403 patients [median (IQR) age 37 (32-43) years; 70% fema

SUBMITTER: Hawkins C 

PROVIDER: S-EPMC4896406 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature