Single-Nucleotide Polymorphisms and Markers of Oxidative Stress in Healthy Women.

ABSTRACT:

Purpose

There is accumulating evidence that oxidative stress is an important contributor to carcinogenesis. We hypothesized that genetic variation in genes involved in maintaining antioxidant/oxidant balance would be associated with overall oxidative stress.

Methods

We examined associations between single nucleotide polymorphisms (SNPs) in MnSOD, GSTP1, GSTM1, GPX1, GPX3, and CAT genes and thiobarbituric acid-reactive substances (TBARS), a blood biomarker of oxidative damage, in healthy white women randomly selected from Western New York (n = 1402). We used general linear models to calculate age-adjusted geometric means of TBARS across the variants. We also examined the associations within strata of menopausal status.

Results

For MnSOD, being heterozygous was associat

SUBMITTER: Minlikeeva AN 

PROVIDER: S-EPMC4896456 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature