Molecular subgroups of adult medulloblastoma: a long-term single-institution study.

ABSTRACT:

Background

Recent transcriptomic approaches have demonstrated that there are at least 4 distinct subgroups in medulloblastoma (MB); however, survival studies of molecular subgroups in adult MB have been inconclusive because of small sample sizes. The aim of this study is to investigate the molecular subgroups in adult MB and identify their clinical and prognostic implications in a large, single-institution cohort.

Methods

We determined gene expression profiles for 13 primary adult MBs. Bioinformatics tools were used to establish distinct molecular subgroups based on the most informative genes in the dataset. Immunohistochemistry with subgroup-specific antibodies was then used for validation within an independent cohort of 201 formalin-fixed MB tumors, in conjunction with a s

SUBMITTER: Zhao F 

PROVIDER: S-EPMC4896550 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature