Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.

ABSTRACT:

Background

The role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect.

Methods

We developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death.

Results

After adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD

SUBMITTER: Ruiz-Canela M 

PROVIDER: S-EPMC4896732 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature