Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650,000 assisted reproductive technology cycles.

ABSTRACT:

Objective

To evaluate the correlation between total gonadotropin dose and live birth rate.

Design

Retrospective analysis.

Setting

Not applicable.

Patient(s)

A total of 658,519 fresh autologous cycles of in vitro fertilization (IVF) reported to the Society for Assisted Reproductive Technology from 2004 to 2012.

Intervention(s)

None.

Main outcome measure(s)

Logistic regression models were fitted to live birth rates with the use of categorized values for total FSH dose and number of oocytes retrieved as the primary predictor variables. To reduce the effect of the most significant confounders that may lead physicians to prescribe higher doses of FSH, additional analyses were performed limited to good-prognosis patients (<35 years of age, body mass ind

SUBMITTER: Baker VL 

PROVIDER: S-EPMC4896751 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature