Dataset Information
Image-based quantification of 3D morphology for bifurcations in the left coronary artery: Application to stent design.
Ontology highlight
ABSTRACT: Background
Improved strategies for stent-based treatment of coronary artery disease at bifurcations require a greater understanding of artery morphology.Objective
We developed a workflow to quantify morphology in the left main coronary (LMCA), left anterior descending (LAD), and left circumflex (LCX) artery bifurcations.Methods
Computational models of each bifurcation were created for 55 patients using computed tomography images in 3D segmentation software. Metrics including cross-sectional area, length, eccentricity, taper, curvature, planarity, branching law parameters, and bifurcation angles were assessed using open-sources software and custom applications. Geometric characterization was performed by comparison of means, correlation, and linear discriminant analysis (LDA).Results
Differences between metrics suggest dedicated or multistent approaches should be tailored for each bifurcation. For example, the side branch of the LCX (i.e., obtuse marginal; OM) was longer than that of the LMCA (i.e., LCXprox) and LAD (i.e., first diagonal; D1). Bifurcation metrics for some locations (e.g., LMCA Finet ratio) provide results and confidence intervals agreeing with prior findings, while revised metric values are presented for others (e.g., LAD and LCX). LDA revealed several metrics that differentiate between artery locations (e.g., LMCA vs. D1, LMCA vs. OM, LADprox vs. D1, and LCXprox vs. D1).Conclusions
These results provide a foundation for elucidating common parameters from healthy coronary arteries and could be leveraged in the future for treating diseased arteries. Collectively the current results may ultimately be used for design iterations that improve outcomes following implantation of future dedicated bifurcation stents. © 2015 Wiley Periodicals, Inc.
SUBMITTER: Ellwein L
PROVIDER: S-EPMC4896847 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Image-based quantification of 3D morphology for bifurcations in the left coronary artery: Application to stent design.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20151119 7
<h4>Background</h4>Improved strategies for stent-based treatment of coronary artery disease at bifurcations require a greater understanding of artery morphology.<h4>Objective</h4>We developed a workflow to quantify morphology in the left main coronary (LMCA), left anterior descending (LAD), and left circumflex (LCX) artery bifurcations.<h4>Methods</h4>Computational models of each bifurcation were created for 55 patients using computed tomography images in 3D segmentation software. Metrics includ ...[more]