Image-based quantification of 3D morphology for bifurcations in the left coronary artery: Application to stent design.

ABSTRACT:

Background

Improved strategies for stent-based treatment of coronary artery disease at bifurcations require a greater understanding of artery morphology.

Objective

We developed a workflow to quantify morphology in the left main coronary (LMCA), left anterior descending (LAD), and left circumflex (LCX) artery bifurcations.

Methods

Computational models of each bifurcation were created for 55 patients using computed tomography images in 3D segmentation software. Metrics including cross-sectional area, length, eccentricity, taper, curvature, planarity, branching law parameters, and bifurcation angles were assessed using open-sources software and custom applications. Geometric characterization was performed by comparison of means, correlation, and linear discriminant analy

SUBMITTER: Ellwein L 

PROVIDER: S-EPMC4896847 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature