Recon 2.2: from reconstruction to model of human metabolism.

ABSTRACT:

Introduction

The human genome-scale metabolic reconstruction details all known metabolic reactions occurring in humans, and thereby holds substantial promise for studying complex diseases and phenotypes. Capturing the whole human metabolic reconstruction is an on-going task and since the last community effort generated a consensus reconstruction, several updates have been developed.

Objectives

We report a new consensus version, Recon 2.2, which integrates various alternative versions with significant additional updates. In addition to re-establishing a consensus reconstruction, further key objectives included providing more comprehensive annotation of metabolites and genes, ensuring full mass and charge balance in all reactions, and developing a model that correctly predicts

SUBMITTER: Swainston N 

PROVIDER: S-EPMC4896983 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature