Cell Deformation by Single-beam Acoustic Trapping: A Promising Tool for Measurements of Cell Mechanics.

ABSTRACT: We demonstrate a noncontact single-beam acoustic trapping method for the quantification of the mechanical properties of a single suspended cell with label-free. Experimentally results show that the single-beam acoustic trapping force results in morphological deformation of a trapped cell. While a cancer cell was trapped in an acoustic beam focus, the morphological changes of the immobilized cell were monitored using bright-field imaging. The cell deformability was then compared with that of a trapped polystyrene microbead as a function of the applied acoustic pressure for a better understanding of the relationship between the pressure and degree of cell deformation. Cell deformation was found to become more pronounced as higher pressure levels were applied. Furthermore, to determine if thi

SUBMITTER: Hwang JY 

PROVIDER: S-EPMC4897707 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature