Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles.

ABSTRACT: In recent years, active targeting strategies by ligand modification have emerged to enhance tumor accumulation of NP, but their clinical application was strictly restricted due to the complex preparation procedures, poor stability and serious toxicity. An effective and clinical translational strategy is required to satisfy the current problems. Interestingly, the internalization of NP is intimately related with cell cycle and the expression of receptors is not only related with cancer types but also cell cycle progression. So the cellular uptake of ligand modified NP may be related with cell cycle. However, few investigations were reported about the relationship between cell cycle and the internalization of ligand modified NP. Herein, cellular uptake of folic acid (FA) modified NP after ut

SUBMITTER: Hu G 

PROVIDER: S-EPMC4897711 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature