Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To elucidate amyotrophic lateral sclerosis (ALS) biomarkers and potential mechanisms of disease, we measured immune cell populations in whole blood from a large cohort of patients with ALS.

Methods

Leukocytes were isolated from the blood of 44 control patients and 90 patients with ALS. The percentages and total numbers of each cell population were analyzed using flow cytometry and matched with patient ALS Functional Rating Scale-Revised (ALSFRS-R) score to correlate leukocyte metrics with disease progression.

Results

We show a significant increase in the percentage of neutrophils and a significant decrease in the percentage of CD4 T cells and CD16(-) monocytes in the blood of patients with ALS compared to controls; however, only CD16(-) monocyte levels corre

SUBMITTER: Murdock BJ 

PROVIDER: S-EPMC4897983 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature