Gender differences in murine pulmonary responses elicited by cellulose nanocrystals.

ABSTRACT:

Background

Cellulose-based materials have been used for centuries to manufacture different goods derived from forestry and agricultural sources. In the growing field of nanocellulose applications, its uniquely engineered properties are instrumental for inventive products coming to competitive markets. Due to their high aspect ratio and stiffness, it is speculated that cellulose nanocrystals (CNC) may cause similar pulmonary toxicity as carbon nanotubes and asbestos, thus posing a potential negative impact on public health and the environment.

Methods

The present study was undertaken to investigate the pulmonary outcomes induced by repeated exposure to respirable CNC. C57BL/6 female and male mice were exposed by pharyngeal aspiration to CNC (40 μg/mouse) 2 times a week for 3 

SUBMITTER: Shvedova AA 

PROVIDER: S-EPMC4898310 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature