Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT).

ABSTRACT:

Objective

Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance for clinicians on the timing, frequency, and amount of mobilization following acute stroke.

Methods

Eligible patients were aged ≥18 years, had confirmed first (or recurrent) stroke, and were admitted to a stroke unit within 24 hours of stroke onset. Patients were randomized to receive very early and frequent mobilization, commencing within 24 hours, or usual care. We used regression analyses and Classification and Regression Trees (CART) to investigate the effect of timing and dose of mobilization on efficacy and safety outcomes, irrespective of assigned treatment group.

Results

A total of 2,104 patients were enrolled, of whom 2,083 (99.0%)

SUBMITTER: Bernhardt J 

PROVIDER: S-EPMC4898313 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature