Copy number variants in the sheep genome detected using multiple approaches.

ABSTRACT:

Background

Copy number variants (CNVs) are a type of polymorphism found to underlie phenotypic variation, both in humans and livestock. Most surveys of CNV in livestock have been conducted in the cattle genome, and often utilise only a single approach for the detection of copy number differences. Here we performed a study of CNV in sheep, using multiple methods to identify and characterise copy number changes. Comprehensive information from small pedigrees (trios) was collected using multiple platforms (array CGH, SNP chip and whole genome sequence data), with these data then analysed via multiple approaches to identify and verify CNVs.

Results

In total, 3,488 autosomal CNV regions (CNVRs) were identified in this study, which substantially builds on an initial survey of the

SUBMITTER: Jenkins GM 

PROVIDER: S-EPMC4898393 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature