ACC interleukin-10 gene promoter haplotype as a breast cancer risk factor predictor among Jordanian females.

ABSTRACT:

Introduction

Interleukin-10 (IL-10) is a multifactorial cytokine with a complex biological role in breast cancer. The aims of this study were to investigate any association between IL-10 gene promoter polymorphisms, 1082A>/G, -819T>C, and -592A>C, or haplotypes and breast cancer risk among Jordanian women and to evaluate any association between the most common haplotype with clinicopathological features of breast cancer.

Patients and methods

A total of 202 breast cancer patients and 210 age-matched healthy control subjects were genotyped for -1082A/G, -819T/C, and -592A/C single nucleotide polymorphisms in the promoter region of the IL-10 gene by polymerase chain reaction-restriction fragment length polymorphism. Study patients and control subjects were recruited from Prince

SUBMITTER: Atoum MF 

PROVIDER: S-EPMC4898410 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature